B-cells integrate antigen-specific signals transduced via the B-cell receptor (BCR) and antigen non-specific co-stimulatory signals provided by cytokines and CD40 ligation in order to produce IgG antibodies.Toll-like receptors (TLRs) also provide co-stimulation, but Jacket the requirement for TLRs to generate T-cell independent and T-cell dependent
The Late Cretaceous dinosaur record in southern South America has been improved recently; particularly with findings from Chorrillo and Cerro Fortaleza formations, both bearing ankylosaur remains, a clade that was not previously recorded Christmas Decor in the Austral Basin.The dinosaur fauna of the type locality of Cerro Fortaleza Formation is kno
Splenic flexure volvulus (SFV) is a very rare condition that is unlikely to be suspected even when a patient has repeated episodes of abdominal pain and dyschezia.We describe the case of SFV diagnosed and treated laparoscopically in the non-volvulus condition.A 14-year-old boy with no medical history had severe left upper abdominal pain and dyschez
Towards higher impact velocities, ballistic events are increasingly determined by the material temperatures.Related effects might range from moderate thermal softening to full phase transition.In particular, it is of great interest to quantify the conditions for incipient or full melting of metals during impact interactions, which result in a trans